The Lost Files of Sherlock Holmes: Case of the Rose Tattoo is a point and click adventure game released in 1996 by Electronic Arts. The game was released for PC (DOS).

In October 1889, the formula of a new and extremely powerful explosive disappeared from the Ministry of Defense. Sherlock's brother, Mycroft, an eccentric but influential government official, initiated an official, though secret, investigation into the theft, but his efforts were thwarted. Just before asking Sherlock to conduct an independent investigation of the theft, Mycroft was seriously injured in an explosion that destroyed the Diogenes club ...

Playing the role of Dr. Watson (in the first episodes of the game), and then Sherlock Holmes, we investigate the explosion that occurred in the club Diogenes.