The Lost Files of Sherlock Holmes is an adventure game series developed by Mythos Software and published by the American computer game company Electronic Arts for DOS in the 1990s.

The player, as Sherlock Holmes, is engaged by Scotland Yard to help with the murder investigation of a young actress. While the manner of her death suggests this is another strike by Jack the Ripper, Holmes believes someone else had committed the crime. The investigation takes Holmes and Watson to many parts of late 19th Century London, including a perfume shop, the zoological gardens, the morgue, a pub, several dwellings, Surrey Commercial Dock, Savoy Street Pier, St Pancras Station, and of course 221B Baker Street.