"The Dagger of Amon Ra" is a continuation of the adventures of Laura Bow, who this time is hired by a New York newspaper to write an article about the latest exhibition presented by the local Leyendecker Museum. First of all, she has to focus on one exhibit - an ancient Egyptian dagger. However, during the reception In honor of the opening of a new section of the museum, a murder occurs and a dagger is stolen.

Technically, "The Dagger of Amon Ra" works similarly to "The Colonel's Bequest", focusing mainly on exploration and collecting clues. The action of the game mostly takes place in museum rooms, although there are exceptions). During the investigation, Laura will interact with characters to gain information and discover their true motivations for the crime. Some information and events may only be available in certain places and at certain times. At the end of the game, Laura will have to present her case to the coroner, which involves answering a series of questions about the crimes. Depending on the playing style, clues discovered, and deduction skills, the player may or may not have the correct answers to all the questions.